Electrochemical sensors for point of use diagnostics from Canatu

Electrochemical biosensors

Electrochemical biosensors using Canatu CNT provide >10-fold increased sensitivity in in vitro matrices. Exceptional sensitivity unlocks unpresented detection capabilities for new assays.

 


Electrochemical biosensors for point-of-care analysis

Electrochemical biosensors using Canatu CNT provides > 10-fold increased sensitivity in in vitro matrices. Superior sensitivity is made possible by our patented  dry deposition technology yielding the most advanced carbon nanotubes (Canatu CNTs) with incredibly extensive and pristine reaction surface area. This enormous, three-dimensional surface provides many binding sites for biorecognition elements to interact with target analytes, enabling stronger signals event in complex matrices. Exceptional sensitivity unlocks unprecedented detection capabilities for new assays. Furthermore, severe infections and diseases, like cancer, can now be detected at an early stage, saving lives and money.

Key benefits

  • Sensitive: >10x higher sensitivity in an in vitro matrix
  • Versatile: platform technology for detecting any analyte of interest
  • At scale: capacity to produce tens of millions of sensors annually
Electrochemical detection using Canatu CNT offers superior signal to background ratio

Over 10x higher sensitivity

Canatu CNT offers the highest sensitivity outside a lab; over ten times more sensitive than anything our competitors can offer. Proven in in vitro matrices, this superior sensitivity enables unprecedented detection capabilities for new assays. It’s achieved through our patented dry deposition™ technology, which allows us to produce carbon nanotubes with uniquely large and pristine reaction surfaces.

Canatu carbon nanotubes click chemistry DNA

Versatile platform technology

Our proprietary click chemistry enables the immobilization of any biorecognition element, including antibodies, DNAs, enzymes, and aptamers, making it a versatile platform technology for detecting any analyte of interest. This offers an unprecedented opportunity to detect severe diseases and infections at their earliest stages. Canatu has, for example, demonstrated pre-metastatic cancer detection by analyzing circulating tumor DNA from small blood samples at the point of care.

At scale

Canatu has the experience and expertise to produce tens of millions of sensors every year. Our patented dry deposition method and electrode patterning process are fully compatible with roll-to-roll production and have been successfully demonstrated at an industrial scale. We have been mass producing our sensors for multiple industries since 2015.

Lab on a chip

Lab on a chip

Simultaneous testing of multiple biomarkers from a single sample is now possible. These analytes can include DNA mutations, pathogens, hormones, and drug molecules. These microfluidic chips offer high sensitivity, portability, and the capability to perform complex analyses with minimal sample consumption. Multiplex assays can be customized at any design to recognize different target analytes with the same sample.

Download technical data

We are looking to partner with frontrunners ready to transform medical diagnostics at the point of care. Download technical data to explore our capabilities further.

Medical diagnostics using electrochemical biosensors from Canatu

Latest research

Canatu has nearly a decade of experience in vitro research. Peer-reviewed references serve as valuable resources for professionals keen on understanding our technology and capabilities. Discover an overview of our latest and most notable publications.

TO LATEST RESEARCH

Versatile platform technology for detecting any analyte of interest

Canatu’s proprietary click chemistry enables the immobilization of biorecognition elements, including antibodies, DNAs, enzymes, and aptamers, making it a versatile platform technology for detecting any analyte of interest, such as pathogens, hormones, DNA mutations, and drug molecules. Canatu has, for example, demonstrated pre-metastatic cancer detection by analyzing circulating tumor DNA from extremely small blood samples right at the point-of-care.
Multiple disease-specific biomarkers can be tested simultaneously from a small blood sample, enabling rapid results and better patient care.

See electrochemical biosensor video

Exceptionally sensitive electrochemical biosensors

Electrochemical biosensor functions by converting biochemical events into electrical signals. At its core is the electrode, providing stable support for immobilizing biomolecules and facilitating electron movement. Carbon nanotubes stand out as ideal electrodes, thanks to their large and pristine surface area, providing many binding sites for the analytes.

Electrochemical biosensors using Canatu CNT offer more than a 10-fold increase in sensitivity in in vitro matrices. This heightened sensitivity is made possible through our patented dry deposition technology, which produces CNTs with exceptionally pristine and large surface areas. To illustrate this, just one gram of Canatu CNTs boasts a surface area equivalent to that of a soccer field. Large surface provides many binding sites for biorecognition elements to attach with the target analytes. Moreover, the unique three-dimensional carbon structure of CNTs enables robust and reliable attachment of biorecognition elements, resulting in stronger signals even within complex matrices.

Unprecedented sensitivity enables new assays and allows for the early detection of severe diseases and infections, even before their onset.

Our patented click chemistry provides a versatile platform technology for detecting any analyte of interest, including DNA mutations, pathogens, hormones, and drug molecules, offering a unique opportunity to diagnose severe diseases, like cancer, or infections at their earliest stages, saving lives and money.

Employing biorecognition elements like DNAs, antibodies, aptamers, and enzymes, click chemistry immobilizes electrodes to specific target analytes, generating electrical signals processed by an electronic system.

Canatu has demonstrated point-of-care molecular diagnostics for early cancer detection by analyzing circulating tumor DNA at extremely low concentrations.

Canatu has the expertise to produce tens of millions of sensors annually. Our patented dry deposition method and electrode patterning process are fully compatible with roll-to-roll production, demonstrated successfully on an industrial scale mass production since 2015. We excel in tailoring our CNTs to meet application-specific requirements. We have extensive experience on post-processing our CNTs, including surface functionalization to immobilize biorecognition elements to enable selectivity for particular target analytes. We have high control of the whole process, and can adjust both individual CNTs and the overall CNT network morphology.

The inherently large specific surface area, high electrical conductivity, and tailorable surface chemistry make Canatu CNT an ideal electrode for electrochemical biosensors, offering industry-leading sensitivity.

Electrochemical biosensors for detecting painkiller concentrations

Canatu has collaborated with leading Finnish universities and Helsinki University Hospital to develop electrode strips for point-of-care measurements of painkiller concentrations. In this partnership, test strips capable of quantitatively detecting painkillers, including paracetamol and opioids, have been created. Given the widespread misuse of these medications, they are common causes of poisoning.

The developed test strips utilize the highly sensitive and repeatable Canatu CNT electrode platform, ensuring a high signal-to-noise ratio. These test strips have been demonstrated in three early clinical studies, including the clinical validation of a test strip designed to measure paracetamol (acetaminophen) concentrations from small finger-prick blood samples.

Contact Ilkka on electrochemical biosensors

Send us a message

We are looking for a partner for product development and commercialization. If you’re interested in exploring this opportunity further, contact our CTO Ilkka Varjos.

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